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Antiphospholipid Syndrome Quiz

In Brief

1) Other names for antiphospholipid syndrome (APS) include all of the following except:

a. anticardiolipin syndrome b. antiphospholipid antibody syndrome (APAS)

c. Hughes syndrome

d. Clarks syndrome

Answer: see below

2) Anticardiolipin syndrome may be a primary disease or secondary, as with SLE, acute infections, HIV, certain cancers, and with some drugs (phentoin or penicillin). True or False?

Answer: see below

3) Antiphospholipid syndrome is an autoimmune, hypercoagulable state causing thrombotic events in arteries and veins. Antiphospholipid antibodies react with cardiolipins and other phospholipids found in cell membranes and platelets. These antibodies include:

Answer: See question 5 below


4) Diagnosis requires at least one clinical criteria and at least one laboratory criteria. What are the clinical criteria?

Answer: See below


5) What are the laboratory criteria?

Answer: See below

Answers

1) Other names for antiphospholipid syndrome (APS) include all of the following except:

a. anticardiolipin syndrome (more specific name)

b. antiphospholipid antibody syndrome (APAS)

c. Hughes syndrome

d. Clarks syndrome

Answer: d

2) Anticardiolipin syndrome may be a primary disease or secondary, as with SLE, acute infections, HIV, certain cancers, and with some drugs (phentoin or penicillin). True or False?

Answer: True

3) Antiphospholipid syndrome is an autoimmune, hypercoagulable state causing thrombotic events in arteries and veins. Antiphospholipid antibodies react with cardiolipins and other phospholipids found in cell membranes and platelets. These antibodies include:

Answer: See question 5 below


4) Diagnosis requires at least one clinical criteria and at least one laboratory criteria. What are the clinical criteria?

Answer: See below

a) Vascular thrombosis (unequivocal arterial, venous or small vessel thrombosis) with no evidence of inflammation in the vessel wall.


b) Pregnancy morbidity

  • Fetal death beyond 10 weeks of gestation

  • Premature birth associated with eclampsia, severe preeclampsia or other placental insufficiency.

  • Three or more unexplained consecutive spontaneous abortions before the 10th week of gestation.

5) What are the laboratory criteria?

Answer: Please enter FibonacciMD.com


If negative lab criteria or low positive and suspect ACLS, repeat laboratory testing in 12 weeks.


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