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4th COVID Vaccine?



Last updated March 30, 2022

What Is the Current Status of a Fourth COVID-19 Vaccine Dose?

Some authorities are now recommending a fourth vaccine dose for selected groups to combat Omicron variant infections. This article will look at those recommendations, and whether they are going to be applicable to the general population.

Update: On February 14th, 2022, Sweden’s public health agency recommended that people living in in nursing homes, receiving assisted-living services at home, or anyone 80 years of age or older should receive a fourth dose (second booster dose) of Pfizer or Moderna COVID-19 vaccine at least four months after their third dose.[12]

Note: Information and recommendations about a fourth COVID-19 vaccination dose are changing rapidly. As new information becomes available this article will be updated. Last updated: March 30, 2022.

The full article includes:

  • CDC Guidelines on a Fourth COVID-19 Vaccine Dose

  • Moderately or Severely Immunocompromised Recommendations

  • CDC COVID-19 vaccination schedule for people who are moderately or severely immunocompromised

  • The Israeli Experience With Fourth COVID-19 Vaccine Doses

  • How Effective Are Three doses of COVID-19 Vaccine?

  • When Will an Omicron Specific Vaccine Be Available?

  • and a conclusion


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[1] Interim Clinical Considerations for Use of COVID-19 Vaccines Currently Approved or Authorized in the United States. CDC website. Updated January 6, 2022. Retrieved from:

[2]Interim Clinical Considerations for Use of COVID-19 Vaccines Currently Approved or Authorized in the United States CDC website. Updated March 30, 2022. Retrieved from:

[3] Kershner I. Israel approves a 4th dose of Covid vaccine for those with compromised immune systems. The New York Times. Dec. 30, 2021. Retrieved from:

[4] Israeli trial, world’s first, finds 4th dose ‘not good enough’ against Omicron. The Times of Israel. Updated: 18 January 2022. Retrieved from:

[5] Israel says 500K have received 4th vaccine dose The Associated Press on ABC news website . January 14, 2022. Retrieved from:

[6] Preliminary Data Analysis: Effectiveness of the Fourth Dose for Older Adults 60 Years of Age and Older. Israeli Ministry of Health. January 23rd, 2022. Retrieved from:

[7] Recommendation: a Fourth Dose to People under 60. Israeli Ministry of Health. January 25, 2022. Retrieved from:

[8]Arbel R et al. Second Booster Vaccine and Covid-19 Mortality in Adults 60 to 100 Years Old. Research Square.

[9] Effectiveness of a Third Dose of mRNA Vaccines Against COVID-19–Associated Emergency Department and Urgent Care Encounters and Hospitalizations Among Adults During Periods of Delta and Omicron Variant Predominance — VISION Network, 10 States, August 2021–January 2022. CDC, Morbidity and Mortality Weekly Report. January 21, 2022. Retrieved from:

[10] Kimball P. Pfizer CEO says omicron vaccine will be ready in March. CNBC. Jan 10 2022. Retrieved from:

[11] Anthes E. ]Moderna begins a study of a booster designed to counter Omicron. The New York Times, January 27, 2022. Retrieved from:

[12] Surman M. Sweden recommends fourth vaccine shots for people 80 and older. The New York Times. February 14, 2022. Retrieved from:


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