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Intermittent Fasting — A Review in Progress


By Zachary A. Knecht, PhD

Atkins, South Beach, Paleo, Keto, Macro—fad diets come and go. One day we are stocking up on bacon and throwing out eggs, and the next we are avoiding any food that might contain a trace of preservatives.

As our understanding of metabolism and nutrition improves, however, losing weight and eating a healthy diet evolves into a highly complex and individualized science.

Enter the recent trend of intermittent fasting, which promotes an eating pattern that is different from the traditional three meals a day that most of us consume...

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Bonassa ACM, Carpinelli AR. Intermittent fasting for three months decreases pancreatic islet mass and increases insulin resistance in Wistar rats. Endocr Abstr. 2018;56:P519.

Goodrick CL, Ingram DK, Reynolds MA, Freeman JR, Cider NL. Differential effects of intermittent feeding and voluntary exercise on body weight and lifespan in adult rats. J Gerontol. 1983;38:36-45.

Goodrick CL, Ingram DK, Reynolds MA, Freeman JR, Cider NL. Effects of intermittent feeding upon growth and life span in rats. Gerontology. 1982;28:233-241.

Johnson JB, Summer W, Cutler RG, et al. Alternate day calorie restriction improves clinical findings and reduces markers of oxidative stress and inflammation in overweight adults with moderate asthma. Free Radic Biol Med. 2007;42:665–674.

Mattson MP, Longo VD, Harvie M. Impact of intermittent fasting on health and disease processes. Ageing Res Rev. 2017;39:46-58.

Solon O. The Silicon Valley execs who don’t eat for days: ‘It’s not dieting, it’s biohacking.’ Web site. September 3, 2017. Accessed September 9, 2019.


Zachary A. Knecht, PhD

Dr. Knecht earned his PhD in Neurobiology at Brandeis University and currently works as a postdoctoral researcher at the Whitehead Institute in Cambridge. His research involves understanding the molecular and cellular basis of tissue regeneration. Outside the lab he enjoys hiking, cooking and spending time with his wife and dog.

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