Renal-cell Carcinoma
InBrief
by Arno Housman, MD
Renal-cell carcinoma (RCC) refers specifically to primary, generally solid tumors arising from the renal cortex (as opposed to those arising from the urothelium of the collecting system).
These tumors actually reflect a diverse collection of lesions of varying histologic origin and different biologic potential and represent 80%–85% of primary renal tumors.The most common solid tumor of the kidney is clear-cell carcinoma, representing ~75% of all RCCs.This type of tumor arises from proximal tubular cells and is most commonly associated with a chromosome-3p deletion.
Other histological cell types of RCC include papillary tumors (~15%–20%) that may arise from the epithelium of the proximal tubule, and chromophobe tumors (~5%) that may arise from the distal nephron.
Further differentiation of cell types is determined by morphology and, possibly, immunohistochemical markers and cytogenetic and molecular genetic analysis. Some 3%–5% of RCCs may remain unclassified.
Read the full Renal-cell Carcinoma InBrief for information on:
Stages, tumor status, and tumor characteristics
Signs and Symptoms
Causes and Risk Factors
Treatment Options
Prognosis
and Pearls to Know
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ABOUT THE AUTHOR
Arno Housman, MD
Dr. Housman graduated from SUNY Downstate Medical Center School of Medicine (now known as SUNY Downstate Health Sciences University), 1980. He stayed on at that institution training in General Surgery before transferring from Brooklyn, New York to New Haven Connecticut where he completed his training in Urology at Yale New Haven Hospital in December of 1986.
While in private practice since January of 1987 Dr. Housman maintained an active interest in medical education and was one of the founding members of his hospital’s Family Practice residency program.
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