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  • Writer's pictureFibonacciMD

The Omega-3 -6 Controversy

Omega: Too Much or Not Enough?


The 2012 National Health Interview Survey, to date, provides the most comprehensive information on complementary health approaches in the U.S. According to the survey, fish oil is one of the most commonly used nonvitamin/nonmineral dietary supplements among adults and children in the U.S. Reasons for fish oil supplementation range from improved heart health to reduced symptoms of ulcerative colitis. However, definitive evidence is lacking to support its use, and the words “may” and “promising” frequently appear in journal articles when discussing omega-3 and -6 supplementation.

Omega-3 fatty acids (generally considered the healthier fatty acids) are essential polyunsaturated fats usually obtained from the human diet. There are three types of omega-3 fatty acids (also called n-3 fatty acids): eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), and a-linolenic acid (ALA). EPA and DHA are found in fatty fish such as wild salmon, lake trout, sardines, anchovies, striped bass, and Arctic char. ALA is the plant form of omega-3 fatty acids found in flax meal, chia seeds, walnuts, and flax seed oil. The conversion of ALA to EPA/DHA is limited.

A multitude of presumed health benefits of omega-3 fatty acids have been shown in research studies. Particularly impressive have been the findings for preventing heart disease. Many studies report some effectiveness of n-3 fatty acids (especially from diet) for reducing triglycerides and metabolic syndrome; decreasing risk of stroke and heart disease; and reducing plaque and arteriosclerosis. Other benefits, according to previous studies, include reducing inflammation, reducing symptoms in rheumatoid arthritis, improving blood vessel elasticity, decreasing clotting, improving cognitive decline and depression, and reducing the risk of macular degeneration. It’s been reported that omega-3 fatty acids might even help regulate heart rhythm and decrease heart rate and blood pressure.

However, in a recent meta-analysis of omega-3 studies (Cochran Database, April 2017, a reviewof 79 trials involving 112,000 participants and mostly involving supplementation with fish oilcapsules), the authors found no “high quality evidence that omega-3 fatty acidssupplementation is effective for improving core and associated symptoms of arterioscleroticheart disease (ASHD).” Furthermore, “given the paucity of rigorous studies in this area, there isa need for large well-c onducted randomized controlled trials...” Although EPA and DHA (theomega-3 fatty acids), especially in the diet reduces serum triglycerides and slightly raises HDL(high-quality evidence), only increasing plant-based ALA may be slightly protective for someheart and circulatory diseases especially anti-arrhythmic effects.

Significant research has also been conducted with omega-3 fatty acids and childhood-associateddiseases such as asthma, cognitive learning disabilities, and autism. In an article in theEuropeanJournal of Clinical Nutrition, the authors reporton a study amongst children with a history ofasthma. In the study, 239 children were randomized to receive tuna fish oil (high in omega-3swith 135 mg DHA, 32 mg EPA, and low in omega-6 fatty acids) or Sunola oil (low in omega-3s,but contains omega-6s) daily from age 6 months to 5 years. The National Assessment ProgramLiteracy and Numeracy (NAPLAN) test was administered in school every 2 years. The authorsconcluded that their findings didn't support administering fatty acids to children in infancy andchildhood to improve academic performance.

Despite experts advocating for large-scale studies to gain “evidence”, omega-3 and omega-6supplementation remains widely seen as beneficial for a panacea of diseases and diagnosesincluding: ADD, psychiatric disorders, cystic fibrosis, macular degeneration, and cancer. On theother hand, quoting an academic- “I don’t recommend supplementation to my patients,” saysVan-Hong Nguyen, MD, FACC, a cardiologist and Assistant Professor, Mt. Sinai Medical Center, in New York. Nguyen is skeptical of anything that’s a “panacea”. “I recommend that my patientsget their omegas through diet.”

So, until further research is conducted and more definitive evidence is in, it’s best to getomega-3 and omega-6 through food. Additionally, there’s also research that supports thedangers of too much of these essential fatty acids: “...There is also evidence that a highomega-6 fatty acid diet inhibits the anti-inflammatory and inflammation-resolving effect of theomega-3 fatty acids. The interaction of omega-3 and omega-6 fatty acids and their lipidmediators in the context of inflammation is complex and still not properly understood.(Prostaglandins Leukot Essential Fatty Acids, 2018May)

The FDA currently recommends that adults get 250-500 mg combined EPA and DHA daily. Forchildren, the Institute of Medicine recommends a daily intake of between 700 mg to 1200 mg,dependent on age.

Good sources of omega-3 include:

  • Fish and other seafood (ie, salmon, mackerel, tuna, herring, sardines)

  • Soybeans and edamame

  • Kidney beans

  • Nuts and seeds (ie, flaxseed, chia seeds, walnuts)

  • Seaweed and algae

  • Fortified foods (ie, eggs, yogurt, juices, milk, soy beverages)

Good sources of omega-6 include:

  • eggs

  • whole grain breads

  • cereals

  • Oils, such as flaxseed, hempseed, grapeseed

  • Seeds, such as: pumpkin, sunflower, flaxseed, hempseed

  • Nuts, including pignolia (pine) and pistachios

In conclusion, the omega-3 and omega-6 (essential polyunsaturated) fatty acids both showhealth benefits. However, when intake of omega-6’s far outweigh the omega-3’s, this mayreverse some of the benefits of the omega-3’s, especially their anti-inflammatory effects. Untilwe have better studies, this author recommends:

  1. Obtaining your fish oil from whole foods rather than from supplementation, asmuch as possible

  2. Replacing your saturated fats with omega-3 and omega-6 fatty oils

  3. Trying to maintain a more favorable ratio of omega-3 to omega-6 (1: 4 or better)


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1.Yokoyama M, Origasa H, Matsuzaki M, et al. Effects of eicosapentaenoic acid on major coronary events in hypercholesterolaemic patients (JELIS): a randomised open-label, blinded endpoint analysis. Lancet. 2007; 369:1090-98.

2. Leitzmann MF, Stampfer MJ, Michaud DS, et al. Dietary intake of n-3 and n-6 fatty acids and the risk of prostate cancer. Am J Clin Nutr. 2004; 80:204-16.

3. Koralek DO, Peters U, Andriole G, et al. A prospective study of dietary alpha-linolenic acid and the risk of prostate cancer (United States). Cancer Causes Control. 2006; 17:783-91.

4. Willett WC. The role of dietary n-6 fatty acids in the prevention of cardiovascular disease. J Cardiovasc Med. (Hagerstown). 2007; 8 Suppl 1:S42-5.

5. Mozaffarian D, Ascherio A, Hu FB, et al. Interplay between different polyunsaturated fatty acids and risk of coronary heart disease in men. Circulation. 2005; 111:157-64.

12. AHRQ, Agency for Healthcare Research and Quality

14. Brew BK, Toelle BG, Webb KL, et al. Omega-3 supplementation during the first 5 years of life and later academic performance: a randomised controlled trial. European Journal of Clinical Nutrition. 2015; 69: 419–424.


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